How can the toxicological data on an SDS indicate "None Reported" for toxicological effects with an end point type of LD50?

Document ID

Document ID TE9357

Version

Version 1.0

Status

Status Published

Published Date

Published Date 02/16/2018
Question
How can the toxicological data on an SDS indicate "None Reported" for toxicological effects with an end point type of LD50?
Summary
How to interpret the toxicological data on a Safety Data Sheet (SDS).
Answer
Section 11 of an SDS is the Toxicological information section. In this section under Ingredient acute toxicity data, the endpoint type is often something like Rat LD50. What this means is that at the reported dose greater than or equal to 50% of the rats in the study died. Commonly under toxicological effects it will indicate none reported. It could be expected that death would be noted as the toxicological effect and that since it says "None Reported," this could be interpreted that none of the rats had died at the reported dose, but if that was the case then a endpoint type of LD50 would not be valid. However, death of at least 50% of the test subjects is implied by the endpoint type being LD50, therefore this field for toxicological effects is for noting if there were any other specific toxicologic effects to report other than death.

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